A significant number of clinical, animal and cell studies have shown the therapeutic effects of pulsed radiofrequency electromagnetic fields on postoperative pain and wound healing. The references below are studies performed with devices that emit pulsed radiofrequency energy at a carrier frequency of 27.12MHz. The carrier frequency of BioElectronics RecoveryRx:
Rawe, I. M. (2014) The Case for Over-the-Counter Shortwave Therapy: Safe and Effective Devices for Pain Management, Pain Management Journal January 2014, Vol. 4, No. 1, Pages 37-43 www.futuremedicine.com
Rawe, I. M. and T. C. Vlahovic (2011). The use of a portable, wearable form of pulsed radio frequency electromagnetic energy device for the healing of recalcitrant ulcers: A case report. Int Wound J. 2011 Sep 20. doi: 10.1111/j.1742-481X.2011.00853.x.
Rawe I.M., Lowenstein A, Barcelo C.R., Genecov D.G. (2011) Control of Postoperative Pain with a Wearable Continuously Operating Pulsed Radiofrequency Energy Device: A Preliminary Study. Aesthetic Plast Surg. Oct 25. DOI 10.1007/s00266-011-9828-3
Frykberg, R.G., Driver, V.R., Lavery, L.A., Armstrong, D.G., and Isenberg, R.A. (2011). The Use of Pulsed Radio Frequency Energy Therapy in Treating Lower Extremity Wounds: Results of a Retrospective Study of a Wound Registry. Ostomy Wound Manage 57, 22-29.
Frykberg, R., Martin, E., Tallis, A., and Tierney, E. (2011). A case history of multimodal therapy in healing a complicated diabetic foot wound: negative pressure, dermal replacement and pulsed radio frequency energy therapies. Int Wound J 8, 132-139.
Maier, M. (2011). “Pulsed radio frequency energy in the treatment of painful chronic cutaneous wounds: a report of two cases.” Pain medicine 12(5): 829-832
Fletcher, S. (2011). Successful treatment of venous stasis ulcers with combination compression therapy and pulsed radio frequency energy in a patient scheduled for amputation. J Wound Ostomy Continence Nurs 38, 91-94.
Rohde, C., Chiang, A., Adipoju, O., Casper, D., and Pilla, A.A. (2009). Effects of Pulsed Electromagnetic Fields on IL-1beta and Post Operative Pain: A Double-Blind, Placebo-Controlled Pilot Study in Breast Reduction Patients. Plast Reconstr Surg.
Heden, P., and Pilla, A.A. (2008). Effects of pulsed electromagnetic fields on postoperative pain: a double-blind randomized pilot study in breast augmentation patients. Aesthetic Plast Surg 32, 660-666.
Porreca, E. G. and G. M. Giordano-Jablon (2008). “Treatment of severe (Stage III and IV) chronic pressure ulcers using pulsed radio frequency energy in a quadriplegic patient.” Eplasty 8: e49.
Larsen, J. A. and J. Overstreet (2008). “Pulsed radio frequency energy in the treatment of complex diabetic foot wounds: two cases.” Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society / WOCN 35(5): 523-52
Mayrovitz, H. N., Sims, N., Macdonaki, J. (2002). Effects of pulsed radio frequency diathermy on postmastectomy arm lymphedema and skin blood flow: a pilot investigation. Lymphology 35:353–356.
Kloth, L. C., Berman, J. E., Sutton, C. H., et al. (1999). Effect of pulsed radio frequency stimulation on wound healing: a double-blind pilot study. In: Bersani, F. Electricity and Magnetism in Biology and Medicine (pp. 875–878). New York: Academic/Plenum.
Salzberg, C.A., Cooper-Vastola, S.A., Perez, F., Viehbeck, M.G., and Byrne, D.W. (1995). The effects of non-thermal pulsed electromagnetic energy on wound healing of pressure ulcers in spinal cord-injured patients: a randomized, double-blind study. Ostomy Wound Manage 41, 42-44, 46, 48 passim.
Santiesteban, A. J., Grant, C. (1985). Post-surgical effect of pulsed shortwave therapy. J. Amer. Podiatr. Med.Assoc. 75:306–309.
Till, M., Gubisch, W., Frickert, G., Reichert, H., and Schmidt, K.H. (1993). [Postoperative management with pulsed high frequency electromagnetic energy. A clinical study of 38 patients with rhinoseptoplasty]. Handchir Mikrochir Plast Chir 25, 26-32.
Comorosan, S., R. Vasilco, et al. (1993). “The effect of diapulse therapy on the healing of decubitus ulcer.” Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale] 30(1-2): 41-45.
Stiller, M.J., Pak, G.H., Shupack, J.L., Thaler, S., Kenny, C., and Jondreau, L. (1992). A portable pulsed electromagnetic field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double-blind, placebo-controlled clinical trial. Br J Dermatol 127, 147-154.
Itoh, M., Montemayor, J.S., Jr., Matsumoto, E., Eason, A., Lee, M.H., and Folk, F.S. (1991). Accelerated wound healing of pressure ulcers by pulsed high peak power electromagnetic energy (Diapulse). Decubitus 4, 24-25, 29-34.
Ieran, M., Zaffuto, S., Bagnacani, M., et al. (1990) Effect of low frequency pulsing electromagnetic fields on skin ulcers of venous origin in humans: a double-blind study. J. Orthop. Res. 8: 276-282.
Bentall, R. H. C. (1986). “Low-level pulsed radiofrequency feilds and the treatment of soft-tissue injuries.” Bioelectrochemistry and Bioenergetics 16: 531-548.
Silver, H. (1982) Reduction of capsular contracture with two-stage augmentation mammaplasty and pulsed electromagnetic energy (Diapulse therapy). Plastic and reconstructive surgery 69, 802-808.
Nicolle FV, Bentall RM.( 1982) Use of radio-frequency pulsed energy in the control of postoperative reaction in blepharoplasty. Aesthetic Plast Surg;6(3): 169-171.
Goldin, J. H., Broadbent, N. R., Nancarrow, J. D., et al. (1981). The effects of Diapulse on the healing of wounds: a double-blind randomised controlled trial in man. Br. J. Plast. Surg. 34:267–270.
Bentall, R. H. C., Eckstein, H. B. (1975). A trial involving the use of pulsed electro-magnetic therapy on children undergoing orchidopexy. Zeitschrift fu¨r Kinderchirurgie 17(4):380–389.
Aronofsky, D.H. (1971). Reduction of dental postsurgical symptoms using nonthermal pulsed high-peak-power electromagnetic energy. Oral Surg Oral Med Oral Pathol 32, 688-696.
Kaplan, E. G., Weinstock, R. E. (1968). Clinical evaluation of diapulse as adjunctive therapy following foot surgery. J. Amer. Podiat. Assoc. 58:218–221.
Cameron, B.M. (1964). A Three Phase Evaluation of Pulsed, High Frequency, Radio Short Waves (Diapulse): 646 Patients. Am J Orthop 6, 72-78.
Li Q, Kao H, Matros E, Peng C, Murphy GF, Guo L. Pulsed Radio Frequency Energy (PRFE) Accelerates Wound Healing In Diabetic Mice. Plast Reconstr Surg 2011; Feb 8
Goudarzi I, Hajizadeh S, Salmani, ME, Abrari, K. Pulsed electromagnetic fields accelerate wound healing in the skin of diabetic rats, Bioelectromagnetics 2010;31, 318-323.
Callaghan MJ, Chang EI, Seiser N, Aarabi, S, Ghali, S, Kinnucan, ER, Simon BJ, and Gurtner GC. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release, Plast Reconstr Surg 2008;121, 130-141.
Moffett, J., Kubat, N. J., Griffin, N. E., et al. Pulsed radio frequency energy field treatment of cells in culture results in increased expression of genes involved in angiogenesis and tissue remodeling during wound healing. The Journal of Diabetic Foot Complications 2011; 3, 30-39.
Moffett, J., Griffin, N., Ritz, M., and George, F. (2010). Pulsed radio frequency energy field treatment of cells in culture results in increased expression of genes involved in the inflammation phase of lower extremity diabetic wound healing. The Journal of Diabetic Foot Complications 2, 57-64.
Gilbert TL, Griffin N, Moffett J, Ritz MC, George FR. (2002) The Provant Wound Closure System induces activation of p44/42 MAP kinase in normal cultured human fibroblasts. Ann N Y Acad Sci. 961:168-171
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